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Structural Biology

Structural biology investigates the architecture of biomolecules at atomic scale. 

Our research is focused on molecular structural biology and our main interests concern the catalytic mechanism of enzymes at a molecular level and the structural determinants of enzyme properties. To that end, we employ experimental techniques (mainly biomolecular X-ray crystallography), but put special emphasis on the application of a whole repertoire of computational methods (such as homology modeling, docking, molecular dynamics simulations, calculation of the electrostatics within a protein,…). We aim at understanding important enzyme characteristics and at exploiting this knowledge to rationally design enzyme mutants with tailor-made properties. In the field of structural bioinformatics we study protein-protein interactions in crystals and try to identification of structural patterns in enzyme active sites which allow the prediction of enzyme function from structure.

ORCID: 0000-0002-3485-9740

Publication List

Contact:
Humboldtstrasse 50/III
8010 Graz
Room: 0045030156
e-mail: karl.gruber(at)uni-graz.at
tel: +43-316-380-5417

ORCID: 0000-0002-2261-958X

Publication list

Contact:
Humboldtstrasse 50/III
8010 Graz
Room:  0045030178
e-mail: walter.keller(at)uni-graz.at
tel: +43-316-380-5423

Our group is working on elucidation of the self-assembly of bacterial S-layer proteins into two-dimensional (2D)-crystalline lattices. In pathogenic bacteria, S-layers contribute to virulence by providing a large, repetitive surface structure to interact with the host cell. This has far-reaching effects on the immune response of the host organism and the development of diseases. The formation of 2D crystalline lattices prevents structural characterization by means of X-ray crystallography and makes cryo-electron microscopy (2D crystals and cryo-tomography) the method of choice.
The focus of the other projects is on the structural and functional characterization of medically relevant proteins, which is mainly performed by X-ray crystallography, cryo-EM (single particle method) and X-ray small angle scattering (SAXS).

ORCID: 0000-0001-7871-6680

Publication List

Contact:
Humboldtstraße 50/III
8010 Graz
Room:  0045030182
e-mail:  tea.pavkov@uni-graz.at 
tel: +43-316-380-5483

Contact

Secretary Structural Biology
Humboldtstraße 50/III
Marlies Leopold Phone:+43 (0)316 380 - 1989

Open for visitors:
Di-Do 9:00 – 12:00

Contact

Secretary Structural Biology
Humboldtstraße 50/III
Dr. Birgit Stückler Phone:+43 (0)316 380 - 1929

Open for visitors:
Mo-Fr: 9:00 – 12:00

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