Structural Biology

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Em.o.Univ.-Prof. Christoph KRATKY

Contact:

Humboldtstrasse 50/III

8010 Graz

e-mail: christoph.kratky(at)uni-graz.at

 

 

Publication list

 

 

Univ.-Prof. Dr. Karl GRUBER

Contact:

Humboldtstrasse 50/III

8010 Graz

Room: 0045030182

e-mail: karl.gruber(at)uni-graz.at

tel: +43-316-380-5417

 

Our research is focused on molecular structural biology and our main interests concern the catalytic mechanism of enzymes at a molecular level and the structural determinants of enzyme properties. To that end, we employ experimental techniques (mainly biomolecular X-ray crystallography), but put special emphasis on the application of a whole repertoire of computational methods (such as homology modeling, docking, molecular dynamics simulations, calculation of the electrostatics within a protein,…). We aim at understanding important enzyme characteristics and at exploiting this knowledge to rationally design enzyme mutants with tailor-made properties. In the field of structural bioinformatics we study protein-protein interactions in crystals and try to identification of structural patterns in enzyme active sites which allow the prediction of enzyme function from structure.

 

Publication List

Working Group

Ao.Univ.-Prof. Dr. Walter KELLER

Contact:

Humboldtstrasse 50/III

8010 Graz

Room:  0045030178

e-mail: walter.keller(at)uni-graz.at

tel: +43-316-380-5423

 

Publication list

Working group

Assoc.-Prof. Dr. Monika OBERER

Contact:

Humboldtstrasse 50/III

8010 Graz

Room:  0045030182

e-mail:  m.oberer@uni-graz.at

tel: +43-316-380-5483

 

The team of Monika Oberer aims at understanding the molecular basis of protein function for which three-dimensional structural knowledge is a prerequisite. The results of our research are always embedded within the biological context, as a protein cannot just be seen as an isolated entity. One long term research focus of the group is to establish structure-function analysis of proteins in intracellular and intravascular lipid metabolism.  These proteins play key roles in many biological systems in controlling the availability of lipids for energy production and as building blocks for synthetic reactions and signaling events. Impaired regulation of these proteins results in different pathological conditions, including cardiovascular disease, type-2 diabetes, and dyslipidemia. The laboratory successfully uses the two major structural techniques, NMR spectroscopy and X-ray crystallography to address our specific research questions. Additionally, biochemical and biophysical techniques are employed to characterize the proteins and their interactions.

 

PhD Programm – doc.funds-CVs

Publication list

Working group

Ao.Univ.-Prof. Dr. Ulrike WAGNER

Contact:

Humboldtstrasse 50/III

8010 Graz

Room: 0045030174

e-mail: ulrike.wagner(at)uni-graz.at

tel: +316-380-5431

 

Publication listu

Working group

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Contact

Secretary Structural Biology
Humboldtstraße 50/III

Marlies Leopold
+43 (0)316 380 - 1989

Open for visitors:
Di-Do 9:00 – 12:00

Contact

Secretary Structural Biology
Humboldtstraße 50/III

Dr. Birgit Stückler
+43 (0)316 380 - 1929

Open for visitors:
Mo-Fr: 9:00 – 12:00

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