We focus on the following topics:
Univ.-Prof. Mag. Dr.rer.nat. Karl Gruber
+43 316 380 - 5417
ORCID: 0000-0002-3485-9740
https://molekularbiologie.uni-graz.at/en/strukturbiologie/
K. Gruber group
Our research focuses on the analysis of structure-function relationships in enzymes. We combine experimental techniques such as X-ray crystallography with computational methods and develop new algorithms for the analysis and structure-based prediction of enzyme properties and for the design of optimized enzyme variants.
Keller group
Assoz. Prof. Mag. Dr.rer.nat. Monika Oberer
+43 316 380 - 5431
ORCID: 0000-0003-2525-9513
https://molekularbiologie.uni-graz.at/en/strukturbiologie/
Oberer group
We study protein function at the molecular level, particularly in relation to lipid metabolism. Our research aims to understand the structure-function relationships of these key proteins and to elucidate their role in energy production, synthesis and signal transduction. Dysregulation of these proteins is associated with diseases such as cardiovascular disease, type 2 diabetes and lipid metabolism disorders. We use X-ray crystallography, NMR spectroscopy as well as biochemical and biophysical methods to characterize the proteins and their interactions.
Pavkov-Keller group
Our research focuses on the characterization of medically relevant proteins such as S-layer proteins, crystalline protein shells of many bacteria and archaea. Using an integrative structural biology approach, we analyze the structure and function, e.g. of the lactobacilli S-layer and its binding to human receptors. We also use prediction methods to calculate symmetric assemblies such as the S-layer proteins.
Mag. Dr.rer.nat. Christian Gruber
+43 316 380 - 5466
ORCID: 0000-0003-0214-449X
https://molekularbiologie.uni-graz.at/en/strukturbiologie/
C. Gruber group
My research focuses on understanding the behaviors of biomolecules. In my group, we use structural bioinformatics, data mining and artificial intelligence, including the "Catalophore" approach, to analyze the structural, functional and thermodynamic properties of biological systems. This method allows deep insights into biological processes that are of great importance in drug and protein research.
Mag. Dr.rer.nat. Nermina Malanovic
Malanovic group
Our main research goal is to develop effective antimicrobial compounds to address the unmet medical need related to antibiotic resistance. We study their mechanisms of action in microorganisms and their effects on the host using compounds from a variety of sources, including humans, animals and plants. In particular, the study of structure-activity relationships serves as a basis for the development of peptide-based therapeutics for diseases associated with bacterial infections.
Daniel group
My research revolves around studying and modifying enzymes. The goal of my group is to unravel the mechanisms governing enzyme function, the factors influencing their properties, and to apply this knowledge in adapting them for various biocatalytic uses. Leveraging X-ray crystallography as a primary method, we can pinpoint the precise three-dimensional structure of enzymes. This serves as the foundation for our work in engineering, repurposing, and redesigning enzymes for enhanced functionality.
PhD-Students
AG Gruber K.
Sahrawat, Amit Singh, Dr.rer.nat. MSc.
AG Oberer
AG Pavkov-Keller
Grininger, Christoph, BSc MSc.
AG Malanovic
AG Daniel
Technical Employees
AG Keller
AG Oberer