Publikationen

2022

Lea Hänschke, Christoph Heier, Santiago José Maya Palacios, Huseyin Erdem Özek, Christoph Thiele, Reinhard Bauer, Ronald P. Kühnlein; Margret H. Bülow

Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging

Front. Aging, 14 February 2022. DOI: 10.3389/fragi.2022.800153.

2021

Victor Girard, Florence Jollivet, Oskar Knittelfelder, Marion Celle, Jean-Noel Arsac, Gilles Chatelain, Daan M Van den Brink, Thierry Baron, Andrej Shevchenko, Ronald P Kühnlein, Nathalie Davoust, Bertrand Mollereau 

Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease

Plos Genetics 2021 Nov 17;17(11):e1009921. DOI: 10.1371/journal.pgen.1009921.

Dennis Pauls, Mareike Selcho, Johanna Räderscheidt, Kelechi M Amatobi, Agnes Fekete, Markus Krischke, Christiane Hermann-Luibl, Ayten Gizem Ozbek-Unal, Nadine Ehmann, Pavel M Itskov, Robert J Kittel, Charlotte Helfrich-Förster, Ronald P Kühnlein, Martin J Mueller, Christian Wegener

Endocrine signals fine-tune daily activity patterns in Drosophila

Current Biology Vol. 32Issue 7p1497–1510.e5. DOI: 10.1016/j.cub.2021.07.002.

Heier, C., Knittelfelder, O., Hofbauer, H., Mende, W., Pörnbacher, I., Schiller, L., Schoiswohl, G., Xie, H., Grönke, S.,  Shevchenko, A., Kühnlein, R. P. 

Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

eLife 2021;10:e63252 DOI: 10.7554/eLife.63252.

Hofbauer, H., Heier, C., Sen Saji, A. K., Kühnlein, R. P.

Lipidome remodeling in aging normal and genetically obese Drosophila males

Insect Biochemistry and Molecular Biology, 2021. 133:103498.  DOI: 10.1016/j.ibmb.2020.103498

2019

Hehlert, P., Hofferek, V., Heier, C., Eichmann, TO., Riedel, D., Rosenberg, J., Takaćs, A., Nagy, HM., Oberer, M., Zimmermann, R., Kühnlein, R. P.

The α/β-hydrolase domain-containing 4 and 5 (ABHD4/5)-related phospholipase Pummelig controls energy storage in Drosophila.

J Lipid Res. 2019 Jun 4. pii: jlr.M092817. DOI: 10.1194/jlr.M092817

Xu, Y., Borcherding, A. F., Heier, C., Tian, G., Roeder, Th., Kühnlein, R. P.

Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.

Scientific Reports 9,6989. 2019. 1-15. DOI: 10.1038/s41598-019-43327-y

2018

Heier, C., Kühnlein, R.P.,

Triacylglycerol Metabolism in Drosophila melanogaster

Genetics December 1,  2018 vol. 210 no. 4 1163-1184. doi.org/10.1534/genetics.118.301583

Palanker-Musselman, L., Kühnlein, R. P.

Drosophila as a model to study obesity and metabolic disease.

The Journal of Experimental Biology. 2018. 221 (Pt Supp 1) jeb163881. doi.org/10.1242/jeb.163881

Korandová, M., Krůček, T., Szakosová, K., Kodrík, D., Kühnlein, R. P., Tomášková, J., and Čapková Frydrychová, R.

Chronic low-dose pro-oxidant treatment stimulates transcriptional activity of telomeric retroelements and increases telomere length in Drosophila,

Journal of Insect Physiology 104, 1-8.. doi.org/10.1016/j.jinsphys.2017.11.002

2017


Rockenfeller, P., Smolnig, M., Diessl, J., Bashir1, M., Schmiedhofer1, V.; Knittelfelder, O., Ring, J.,  Franz, J., Foessl, I., Khan, M. J., Rost, R.,; Graier, W. F., Eisenberg, T., Kroemer, G., Zimmermann, A., Carmona-Gutierrez1, D., Büttner, S., Sigrist, S. J., Kühnlein, R. P., Kohlwein, S. D., Gourlay, C. W., Madeo, F.

Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity.

Cell Death and Differentiation. 9. 2017. 1-12. doi::10.1038/s41418-017-0014-2

Gáliková, M., Klepsatel, P., Münch, J., and Kühnlein, R. P. (2017).

Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila.

Scientific Reports 7: 46516. doi:10.1038/srep46516

2016

Gáliková, M., Klepsatel, P., Xu, Y., and Kühnlein, R. P.

The obesity-related Adipokinetic hormone controls feeding and expression of neuropeptide regulators of Drosophila metabolism.

European Journal of Lipid Science and Technology 118. doi: 10.1002/ejlt.201600138

Klepsatel, P., Gáliková, M., Xu, Y., and Kühnlein, R. P.

Thermal stress depletes energy reserves in Drosophila.

Scientific Reports 6. doi:10.1038/srep33667

2015

Gáliková, M., Diesner, M., Klepsatel, P., Hehlert, P., Xu, Y., Bickmeyer, I., Predel, R., and Kühnlein, R.P.

Energy Homeostasis Control in Drosophila Adipokinetic Hormone Mutants.

Genetics 201 (2), 665-683. doi:10.1534/genetics.115.178897

2014

Baumbach, J., Xu, Y., Hehlert, P., and Kühnlein, R. P.

G(alpha)q, G(gamma)1 and Plc21C control Drosophila body fat storage.

Journal of Genetics and Genomics 41 (5), 283-292. doi: 10.1016/j.jgg.2014.03.005

Baumbach, J., Hummel, P., Bickmeyer, I., Kowalczyk, K.M., Frank, M., Knorr, K., Hildebrandt, A., Riedel, D., Jäckle, H., and Kühnlein, R. P.

A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity.

Cell Metabolism 19, 331-343. doi:10.1016/j.cmet.2013.12.004

2012

Birner-Gruenberger, R., Lange, J., Hehlert, P., Bickmeyer, I., Hermetter, A., Kollroser, M., Rechberger G.N., and Kühnlein, R. P.

Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster (alpha)Esterase-7.                                                                                          

Insect Biochemistry and Molecular Biology 42, 220-229. doi: 10.1016/j.ibmb.2011.12.004

Bi, J., Xiang, Y.,  Chen, H.,  Liu, Z.,  Grönke, S., Kühnlein, R. P.,  and Huang, X.

Opposite and redundant roles of the two Drosophila Perilipins in lipid mobilization.

Journal of Cell Science 125, 3568-3577. doi10.1242/jcs.101329

Li, Zhihuan, Thiel, K., Thul, P.J., Beller, M., Kühnlein, R. P., and Welte, M.A. 

Lipid droplets control the maternal histone supply of Drosophila embryos.

Current Biology 22, 2104-2113. DOI: 10.1016/j.cub.2012.09.018

Kühnlein, R. P.

Lipid droplet-based Storage Fat Metabolism in Drosophila.

Journal of Lipid Research 53, 1430-1436. doi: 10.1016/j.plipres.2011.04.001

2011

Kühnlein, R. P. 

The contribution of the Drosophila model to lipid droplet research

Progress in Lipid Research 50 (4), 348-356. doi:10.1016/j.plipres.2011.04.001

Hildebrandt, A., Bickmeyer, I. and Kühnlein, R. P.

Reliable Drosophila body fat quantification by a coupled colorimetric assay.

PLoS ONE 6(9): e23796. doi:10.1371/journal.pone.0023796

2010

Beller, M., Bulankina, A.V., Hsiao, H.-H., Urlaub, H., Jäckle, H., and Kühnlein, R. P.

PERILIPIN-dependent Control of Lipid Droplet Structure and Fat Storage in Drosophila.

Cell Metabolism 12 (5), 521-532. doi:  10.1016/j.cmet.2010.10.001

Kühnlein, R. P. 

Drosophila as lipotoxicity model organism - more than a promise?

Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids 1801 (3), 215-221. doi: 10.1016/j.bbalip.2009.09.006.

Kühnlein, R. P.

Energy homeostasis regulation in Drosophila: A lipocentric perspective.

Results and problems in cell differentiation 52, 159-173. doi:  10.1007/978-3-642-14426-4_13.

2009

Grönke, S., Bickmeyer, I., Wunderlich, R., Jäckle, H. and Kühnlein, R. P.

Curled Encodes the Drosophila Homolog of the Vertebrate Circadian Deadenylase Nocturnin.

Genetics 183 (1), 219-232; doi:  10.1534/genetics.109.105601.

2007

Grönke, S., Müller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., Jäckle, H., and Kühnlein, R. P.

Dual lipolytic control of body fat storage and mobilization in Drosophila.

PLoS Biology 5 (6), e137 doi:10.1371/journal.pbio.0050137

2006

Beller, M., Riedel, D., Jänsch, L., Dieterich, G., Wehland, J., Jäckle, H. and Kühnlein, R. P.

Characterization of the Drosophila lipid droplet subproteome.

Molecular & Cellular Proteomics 5 (6), 1082-1094. doi: 10.1074/mcp.M600011-MCP200

Döring, F., Scholz, H., Kühnlein, R.P., Karschin, A. and Wischmeyer, E. 

Novel Drosophila two-pore domain K+ channels: rescue of channel function by heteromeric assembly.

European Journal of Neuroscience 24 (8), 2264-2274.

2005

Grönke, S., Mildner, A., Fellert, S., Tennagels, N., Petry, S., Müller, G., Jäckle, H. and Kühnlein, R. P.

Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila.

Cell Metabolism 1 (5), 323-330. doi: 10.1016/j.cmet.2005.04.003

2003

Grönke, S., Beller, M., Fellert, S., Ramakrishnan, H., Jäckle, H. and Kühnlein, R. P.

Control of Fat Storage by a Drosophila PAT Domain Protein.

Current Biology 13 (7), 603-606. doi: 10.1016/S0960-9822(03)00175-1

Häder, T., Müller, S., Aguilera, M., Eulenberg, K. G., Steuernagel, A., Ciossek, T., Kühnlein, R. P., Lemaire, L., Fritsch, R., Dohrmann, C., Vetter, I. R., Jäckle, H., Doane, W. W. and Brönner, G.

Control of triglyceride storage by a WD40/TPR-domain protein.

EMBO Reports 4 (5), 511-516.