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Fanaee-Danesh E, Gali CC, Tadic J, Zandl-Lang M, Kober A, Agujetas VR, de Dios C, Tam-Amersdorfer C, Stracke A, Albrecher NM, Manavalan APC, Reiter M, Sun Y, Colell A, Madeo F, Malle E, Panzenboeck U. Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid beta and cholesterol homeostasis in blood-brain barrier endothelial cells. Biochim Biophys Acta Mol Basis Dis. 2019 May 2. pii: S0925-4439(19)30147-4. doi: 10.1016/j.bbadis.2019.04.019. [Epub ahead of print] PubMed PMID: 31055081.

Wirth M, Schwarz C, Benson G, Horn N, Buchert R, Lange C, Köbe T, Hetzer S, Maglione M, Michael E, Märschenz S, Mai K, Kopp U, Schmitz D, Grittner U, Sigrist SJ, Stekovic S, Madeo F, Flöel A. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial. Alzheimers Res Ther. 2019 May 1;11(1):36. doi: 10.1186/s13195-019-0484-1. PubMed PMID: 31039826.

Farrugia G, Azzopardi M, Saliba C, Grech G, Gross AS, Pistolic J, Benes V, Vassallo N, Borg J, Madeo F, Eisenberg T, Balzan R. Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells. Sci Rep. 2019 Apr 16;9(1):6152. doi: 10.1038/s41598-019-39489-4. PubMed PMID: 30992471; PubMedCentral PMCID: PMC6468118.

Bhukel A, Beuschel CB, Maglione M, Lehmann M, Juhász G, Madeo F, Sigrist SJ. Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. Nat Commun. 2019 Mar 21;10(1):1318. doi: 10.1038/s41467-019-09262-2. PubMed PMID: 30899013; PubMed Central PMCID: PMC6428838.

Madeo F, Carmona-Gutierrez D, Hofer SJ, Kroemer G. Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and TherapeuticPotential. Cell Metab. 2019 Mar 5;29(3):592-610. doi: 10.1016/j.cmet.2019.01.018. Review. PubMed PMID: 30840912.

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w. PubMed PMID: 30783116; PubMed Central PMCID: PMC6381180.

Wierich MC, Schipke J, Brandenberger C, Abdellatif M, Eisenberg T, Madeo F, Sedej S, Mühlfeld C. Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice. Exp Gerontol. 2019 May;119:82-88. doi: 10.1016/j.exger.2019.01.026. Epub 2019 Jan 28. PubMed PMID: 30703435.

Abdellatif M, Sedej S, Madeo F, Kroemer G. Cardioprotective effects of autophagy induction in sepsis. Ann Transl Med. 2018 Nov;6(Suppl 1):S61. doi:10.21037/atm.2018.10.23. PubMed PMID: 30613636; PubMed Central PMCID: PMC6291539.

Pechlaner R, Madeo F, Eisenberg T, Kroemer G, Tilg H, Willeit J, Kiechl S. Reply to Gostner and Fuchs. Am J Clin Nutr. 2019 Jan 1;109(1):218-219. doi: 10.1093/ajcn/nqy222. PubMed PMID: 30576412.


Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G. Aspirin Recapitulates Features of Caloric Restriction. Cell Rep. 2018 Feb 27;22(9):2395-2407. doi: 10.1016/j.celrep.2018.02.024. PubMed PMID: 29490275; PubMed Central PMCID: PMC5848858.

Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O, Kroemer G. Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine. 2018 Apr;30:261-272. doi: 10.1016/j.ebiom.2018.03.028. Epub 2018 Mar 27. PubMed PMID: 29606629; PubMed Central PMCID: PMC5952403.

Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4. PubMed PMID: 30388439.

Abdellatif M, Sedej S, Carmona-Gutierrez D, Madeo F, Kroemer G. Autophagy in Cardiovascular Aging. Circ Res. 2018 Sep 14;123(7):803-824. doi: 10.1161/CIRCRESAHA.118.312208. PubMed PMID: 30355077.

Pietrocola F, Castoldi F, Kepp O, Carmona-Gutierrez D, Madeo F, Kroemer G. Spermidine reduces cancer-related mortality in humans. Autophagy. 2018 Oct 24:1-4. doi: 10.1080/15548627.2018.1539592. [Epub ahead of print] PubMed PMID: 30354939; PubMed Central PMCID: PMC6333461.

Kroemer G, López-Otín C, Madeo F, de Cabo R. Carbotoxicity-Noxious Effects of Carbohydrates. Cell. 2018 Oct 18;175(3):605-614. doi: 10.1016/j.cell.2018.07.044.Review. PubMed PMID: 30340032; PubMed Central PMCID: PMC6265656.

Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. PubMed PMID: 30306826; PubMed Central PMCID: PMC6287690.

Hofer S, Kainz K, Zimmermann A, Bauer MA, Pendl T, Poglitsch M, Madeo F, Carmona-Gutierrez D. Studying Huntington's Disease in Yeast: From Mechanisms to Pharmacological Approaches. Front Mol Neurosci. 2018 Sep 4;11:318. doi:10.3389/fnmol.2018.00318. eCollection 2018. Review. PubMed PMID: 30233317; PubMed Central PMCID: PMC6131589.

Madeo F, Carmona-Gutierrez D, Kepp O, Kroemer G. Spermidine delays aging in humans. Aging (Albany NY). 2018 Aug 6;10(8):2209-2211. doi: 10.18632/aging.101517. PubMed PMID: 30082504; PubMed Central PMCID: PMC6128428.



Tripolt NJ, Stekovic S, Aberer F, Url J, Pferschy PN, Schröder S, Verheyen N, Schmidt A, Kolesnik E, Narath SH, Riedl R, Obermayer-Pietsch B, Pieber TR, Madeo F, Sourij H. Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial. Adv Ther. 2018 Aug;35(8):1265-1283. doi: 10.1007/s12325-018-0746-5. Epub 2018 Jul 25. PubMed PMID: 30046988; PubMed Central PMCID: PMC6096974.

Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L,  Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102. PubMed PMID: 29955838.

Zimmermann A, Hofer S, Pendl T, Kainz K, Madeo F, Carmona-Gutierrez D. Yeast as a tool to identify anti-aging compounds. FEMS Yeast Res. 2018 Sep 1;18(6). doi: 10.1093/femsyr/foy020. PubMed PMID: 29905792; PubMed Central PMCID: PMC6001894.

Bauer MA, Kainz K, Carmona-Gutierrez D, Madeo F. Microbial wars: Competition in ecological niches and within the microbiome. Microb Cell. 2018 May 7;5(5):215-219. doi: 10.15698/mic2018.05.628. PubMed PMID: 29796386; PubMed Central PMCID: PMC5961915.

Guaragnella N, Stirpe M, Burhans W, Côrte-Real M, Gourlay C, Ludovico P, Madeo F, Petranovic D, Winderickx J, Mazzoni C, Giannattasio S. New perspectives from South-Y-East, not all about death. A report of the 12(th) lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017. Microb Cell. 2018 Jan 16;5(2):112-115. doi: 10.15698/mic2018.02.616. PubMed PMID: 29417059; PubMed Central PMCID: PMC5798410.

Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018 Jan 26;359(6374). pii: eaan2788. doi: 10.1126/science.aan2788. Review. PubMed PMID: 29371440.
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Galluzzi L, Vitale I, Aaronson SA, Abrams JM, … Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Jan 23. doi: 10.1038/s41418-017-0012-4. [Epub ahead of print] Review. PubMed PMID: 29362479.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, … Guidelines and recommendations on yeast cell death nomenclature. Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. PubMed PMID: 29354647; PubMed Central PMCID: PMC5772036.

Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A. Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354. PubMed PMID: 29315079.



Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F. Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin. Microb Cell. 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603. PubMed PMID: 29234670; PubMed Central PMCID: PMC5722644.

Rockenfeller P, Smolnig M, Diessl J, Bashir M, Schmiedhofer V, Knittelfelder O, Ring J, Franz J, Foessl I, Khan MJ, Rost R, Graier WF, Kroemer G, Zimmermann A, Carmona-Gutierrez D, Eisenberg T, Büttner S, Sigrist SJ, Kühnlein RP, Kohlwein SD, Gourlay CW, Madeo F. Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity. Cell Death Differ. 2017 Dec 11. doi: 10.1038/s41418-017-0014-2. [Epub ahead of print] PubMed PMID: 29230001.

Zechner R, Madeo F, Kratky D. Cytosolic lipolysis and lipophagy: two sides of the same coin. Nat Rev Mol Cell Biol. 2017 Aug 30. doi: 10.1038/nrm.2017.76. [Epub ahead of print] Review. PubMed PMID: 28852221.

Stekovic S, Ruckenstuhl C, Royer P, Winkler-Hermaden C, Carmona-Gutierrez D, Fröhlich KU, Kroemer G, Madeo F. The neuroprotective steroid progesterone promotes mitochondrial uncoupling, reduces cytosolic calcium and augments stress  resistance in yeast cells. Microb Cell. 2017 May 31;4(6):191-199. doi: 10.15698/mic2017.06.577. PubMed PMID: 28660203; PubMed Central PMCID: PMC5473691.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review. PubMed PMID: 28596378; PubMed Central PMCID: PMC5494474

Carmona-Gutierrez D, Kainz K, Madeo F. Sexually transmitted infections: old foes on the rise. Microb Cell. 2016 Sep 5;3(9):361-362. doi: 10.15698/mic2016.09.522. PubMed PMID: 28357374; PubMed Central PMCID: PMC5354564

Zimmermann A, Kainz K, Andryushkova A, Hofer S, Madeo F, Carmona-Gutierrez D. Autophagy: one more Nobel Prize for yeast. Microb Cell. 2016 Dec 5;3(12):579-581. doi: 10.15698/mic2016.12.544. PubMed PMID: 28357329; PubMed Central PMCID: PMC5348976.

Kainz K, Tadic J, Zimmermann A, Pendl T, Carmona-Gutierrez D, Ruckenstuhl C, Eisenberg T, Madeo F. Methods to Assess Autophagy and Chronological Aging in Yeast. Methods Enzymol. 2017;588:367-394. doi: 10.1016/bs.mie.2016.09.086. Epub 2016 Nov 22. PubMed PMID: 28237110. 

Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Dietary spermidine for lowering high blood pressure. Autophagy. 2017 Jan 24:0. doi: 10.1080/15548627.2017.1280225. [Epub ahead of print] PubMed PMID: 28118075.

Pietrocola F, Demont Y, Castoldi F, Enot D, Durand S, Semeraro M, Baracco EE,  Pol J, Bravo-San Pedro JM, Bordenave C, Levesque S, Humeau J, Chery A, Métivier D, Madeo F, Maiuri MC, Kroemer G. Metabolic effects of fasting on human and mouse blood in vivo. Autophagy. 2017 Jan 6:1-12. doi: 10.1080/15548627.2016.1271513. [Epub ahead of print] PubMed PMID: 28059587.

Bhukel A, Madeo F, Sigrist SJ. Spermidine boosts autophagy to protect from synapse aging. Autophagy. 2017 Feb;13(2):444-445. doi: 10.1080/15548627.2016.1265193. PubMed PMID: 28026976.


Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. PubMed PMID: 27841876.

Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K. Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep. 2016 Oct 21;6:35571. doi: 10.1038/srep35571. PubMed PMID: 27767193; PubMed Central PMCID: PMC5073296.

Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel  M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ. Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release. PLoS Biol. 2016 Sep 29;14(9):e1002563. doi: 10.1371/journal.pbio.1002563. PubMed PMID: 27684064; PubMed Central PMCID: PMC5042543.

Pietrocola F, Pol J, Vacchelli E, Baracco EE, Levesque S, Castoldi F, Maiuri MC, Madeo F, Kroemer G. Autophagy induction for the treatment of cancer. Autophagy. 2016 Oct 2;12(10):1962-1964. PubMed PMID: 27532519; PubMed Central PMCID: PMC5079541.

López-Otín C, Galluzzi L, Freije JM, Madeo F, Kroemer G. Metabolic Control of Longevity. Cell. 2016 Aug 11;166(4):802-21. doi: 10.1016/j.cell.2016.07.031. Review. PubMed PMID: 27518560.

Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, Chery A, Lachkar S, Sigl V, Bloy N, Buque A, Falzoni S, Ryffel B, Apetoh  L, Di Virgilio F, Madeo F, Maiuri MC, Zitvogel L, Levine B, Penninger JM, Kroemer G. Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 2016 Jul 11;30(1):147-60. doi: 10.1016/j.ccell.2016.05.016. PubMed PMID: 27411589.

Rockenfeller P, Carmona-Gutierrez D, Pietrocola F, Kroemer G, Madeo F. Ethanolamine: A novel anti-aging agent. Mol Cell Oncol. 2015 Mar 19;3(1):e1019023. doi: 10.1080/23723556.2015.1019023. PubMed PMID: 27308532; PubMed Central PMCID: PMC4845168.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. Effects of Sex,  Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 Jun 14;23(6):1093-112. doi: 10.1016/j.cmet.2016.05.027. PubMed PMID: 27304509; PubMed Central PMCID: PMC4911707.

Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C. The crucial impact of lysosomes in aging and longevity. Ageing Res Rev. 2016 Dec;32:2-12. doi:10.1016/j.arr.2016.04.009. Review. PubMed PMID: 27125853; PubMed Central PMCID: PMC5081277.

Klionsky DJ et al, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P. Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Front Immunol.  2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. PubMed PMID: 26635802; PubMed Central PMCID: PMC4653610.



Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P., Molecular and Translational Classification of DAMPs in Immunogenic Cell Death, Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

Enot DP, Niso-Santano M, Durand S, Chery A, Pietrocola F, Vacchelli E, Madeo F, Galluzzi L, Kroemer G. Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo. Cell Cycle. 2015 Aug 3;14(15):2399-407. doi: 10.1080/15384101.2015.1064206. Epub 2015 Jun 22. PubMed PMID: 26098646.

Pietrocola F, Galluzzi L, Bravo-San Pedro JM, Madeo F, Kroemer G. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21. doi: 10.1016/j.cmet.2015.05.014. Review. PubMed PMID: 26039447.

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, Faggioni A,Formenti SC, Fučíková J, Gabriele L, Gaipl US, Galon J, Garg A, Ghiringhelli F, Giese NA, Guo ZS, Hemminki A, Herrmann M, Hodge JW, Holdenrieder S, Honeychurch J, Hu HM, Huang X, Illidge TM, Kono K, Korbelik M, Krysko DV, Loi S, Lowenstein PR, Lugli E, Ma Y, Madeo F, Manfredi AA, Martins I, Mavilio D, Menger L, Merendino N, Michaud M, Mignot G, Mossman KL, Multhoff G, Oehler R, Palombo F, Panaretakis T, Pol J, Proietti E, Ricci JE, Riganti C, Rovere-Querini P, Rubartelli A, Sistigu A, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Sukkurwala AQ, Tartour E, Thorburn A, Thorne SH, Vandenabeele P, Velotti F, Workenhe ST, Yang H, Zong WX, Zitvogel L, Kroemer G, Galluzzi L. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2014 Dec 13;3(9):e955691. eCollection 2014 Oct. Review. PubMed PMID: 25941621; PubMed Central PMCID: PMC4292729.

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. PubMed PMID: 25902704; PubMed Central PMCID: PMC4531065.

Libiseller G, Dvorzak M, Kleb U, Gander E, Eisenberg T, Madeo F, Neumann S, Trausinger G, Sinner F, Pieber T, Magnes C. IPO: a tool for automated optimization of XCMS parameters. BMC Bioinformatics. 2015 Apr 16;16:118. doi: 10.1186/s12859-015-0562-8. PubMed PMID: 25888443; PubMed Central PMCID: PMC4404568.

Braun RJ, Sommer C, Leibiger C, Gentier RJ, Dumit VI, Paduch K, Eisenberg T, Habernig L, Trausinger G, Magnes C, Pieber T, Sinner F, Dengjel J, van Leeuwen FW, Kroemer G, Madeo F. Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin. Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00137-0. doi: 10.1016/j.celrep.2015.02.009. [Epub ahead of print] PubMed PMID: 25753421; PubMed Central PMCID: PMC4407011.

Niso-Santano M, Bravo-San Pedro JM, Maiuri MC, Tavernarakis N, Cecconi F, Madeo F, Codogno P, Galluzzi L, Kroemer G. Novel inducers of BECN1-independent autophagy: cis-unsaturated fatty acids. Autophagy. 2015;11(3):575-7. doi: 10.1080/15548627.2015.1017222. PubMed PMID: 25714112; PubMed Central PMCID: PMC4502685.


Carmona-Gutierrez D, Zimmermann A, Madeo F. A molecular mechanism for lipophagy regulation in the liver. Hepatology. 2015 Jun;61(6):1781-3. doi: 10.1002/hep.27738. Epub 2015 Apr 15. PubMed PMID: 25677364.

Madeo F, Zimmermann A, Maiuri MC, Kroemer G. Essential role for autophagy in life span extension. J Clin Invest. 2015 Jan;125(1):85-93. doi: 10.1172/JCI73946. Epub 2015 Jan 2. Review. PubMed PMID: 25654554; PubMed Central PMCID: PMC4382258.

Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G. Unsaturated fatty acids induce non-canonical autophagy. EMBO J. 2015 Apr 15;34(8):1025-41. doi: 10.15252/embj.201489363. Epub 2015 Jan 13. PubMed PMID: 25586377; PubMed Central PMCID: PMC4406650.

Rockenfeller P, Koska M, Pietrocola F, Minois N, Knittelfelder O, Sica V, Franz J, Carmona-Gutierrez D, Kroemer G, Madeo F. Phosphatidylethanolamine positively regulates autophagy and longevity. Cell Death Differ. 2015 Mar;22(3):499-508. doi: 10.1038/cdd.2014.219. Epub 2015 Jan 9. PubMed PMID: 25571976; PubMed Central PMCID: PMC4326582.

Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015 Jan 15;160(1-2):132-44. doi: 10.1016/j.cell.2014.11.048. Epub 2014 Dec 23. PubMed PMID: 25542313; PubMed Central PMCID: PMC4297538.

Pietrocola F, Lachkar S, Enot DP, Niso-Santano M, Bravo-San Pedro JM, Sica V, Izzo V, Maiuri MC, Madeo F, Mariño G, Kroemer G. Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 2015 Mar;22(3):509-16. doi: 10.1038/cdd.2014.215. Epub 2014 Dec 19. PubMed PMID: 25526088; PubMed Central PMCID: PMC4326581.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Review. PubMed PMID: 25236395; PubMed Central PMCID: PMC4262782.



Mariño G, Pietrocola F, Madeo F, Kroemer G. Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers. Autophagy. 2014;10(11):1879-82. doi: 10.4161/auto.36413. PubMed PMID: 25484097; PubMed Central PMCID: PMC4502795.

Büttner S, Broeskamp F, Sommer C, Markaki M, Habernig L, Alavian-Ghavanini A,  Carmona-Gutierrez D, Eisenberg T, Michael E, Kroemer G, Tavernarakis N, Sigrist SJ, Madeo F. Spermidine protects against α-synuclein neurotoxicity. Cell Cycle. 2014;13(24):3903-8. doi: 10.4161/15384101.2014.973309. PubMed PMID: 25483063.

Kozieł R, Ruckenstuhl C, Albertini E, Neuhaus M, Netzberger C, Bust M, Madeo F, Wiesner RJ, Jansen-Dürr P. Methionine restriction slows down senescence in human diploid fibroblasts. Aging Cell. 2014 Dec;13(6):1038-48. doi: 10.1111/acel.12266. Epub 2014 Oct 1. PubMed PMID: 25273919; PubMed Central PMCID: PMC4326930.

Madeo F, Pietrocola F, Eisenberg T, Kroemer G. Caloric restriction mimetics: towards a molecular definition. Nat Rev Drug Discov. 2014 Oct;13(10):727-40. doi: 10.1038/nrd4391. Epub 2014 Sep 12. PubMed PMID: 25212602.

Mossmann D, Vögtle FN, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N,  Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C. Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab. 2014 Oct 7;20(4):662-9. doi: 10.1016/j.cmet.2014.07.024. Epub 2014 Aug 28. PubMed PMID: 25176146.

de Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F. The search for antiaging interventions: from elixirs to fasting regimens. Cell. 2014 Jun 19;157(7):1515-26. doi: 10.1016/j.cell.2014.05.031. Review. PubMed PMID: 24949965; PubMed Central PMCID: PMC4254402.

Schroeder S, Pendl T, Zimmermann A, Eisenberg T, Carmona-Gutierrez D, Ruckenstuhl C, Mariño G, Pietrocola F, Harger A, Magnes C, Sinner F, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity. Autophagy. 2014 Jul;10(7):1335-7. doi: 10.4161/auto.28919. Epub 2014 May 15. PubMed PMID: 24904996; PubMed Central PMCID: PMC4203557.

Eisenberg T, Schroeder S, Büttner S, Carmona-Gutierrez D, Pendl T, Andryushkova A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Magnes C, Sinner F, Sedej S, Pieber TR, Dengjel J, Sigrist S, Kroemer G, Madeo F. A histone point mutation that switches on autophagy. Autophagy. 2014 Jun;10(6):1143-5. doi: 10.4161/auto.28767. PubMed PMID: 24879160; PubMed Central PMCID: PMC4091175.

Ruckenstuhl C, Netzberger C, Entfellner I, Carmona-Gutierrez D, Kickenweiz T, Stekovic S, Gleixner C, Schmid C, Klug L, Sorgo AG, Eisenberg T, Büttner S, Mariño G, Koziel R, Jansen-Dürr P, Fröhlich KU, Kroemer G, Madeo F. Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification. PLoS Genet. 2014 May 1;10(5):e1004347. doi: 10.1371/journal.pgen.1004347. eCollection 2014 May. PubMed PMID: 24785424; PubMed Central PMCID: PMC4006742.

Pietrocola F, Malik SA, Mariño G, Vacchelli E, Senovilla L, Chaba K, Niso-Santano M, Maiuri MC, Madeo F, Kroemer G. Coffee induces autophagy in vivo.  Cell Cycle. 2014;13(12):1987-94. doi: 10.4161/cc.28929. Epub 2014 Apr 25. PubMed PMID: 24769862; PubMed Central PMCID: PMC4111762.

Mariño G, Pietrocola F, Kong Y, Eisenberg T, Hill JA, Madeo F, Kroemer G. Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy. Autophagy. 2014 May;10(5):930-2. doi: 10.4161/auto.28235. Epub 2014 Mar 20. PubMed PMID: 24675140.

Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014 Mar 4;19(3):431-44. doi: 10.1016/j.cmet.2014.02.010. PubMed PMID: 24606900; PubMed Central PMCID: PMC3988959.

Mariño G, Pietrocola F, Eisenberg T, Kong Y, Malik SA, Andryushkova A, Schroeder S, Pendl T, Harger A, Niso-Santano M, Zamzami N, Scoazec M, Durand S, Enot DP, Fernández ÁF, Martins I, Kepp O, Senovilla L, Bauvy C, Morselli E, Vacchelli E, Bennetzen M, Magnes C, Sinner F, Pieber T, López-Otín C, Maiuri MC,  Codogno P, Andersen JS, Hill JA, Madeo F, Kroemer G. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. doi: 10.1016/j.molcel.2014.01.016. Epub 2014 Feb 20. PubMed PMID: 24560926.

Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F. Spermidine-triggered autophagy ameliorates memory during aging. Autophagy. 2014 Jan;10(1):178-9. doi: 10.4161/auto.26918. Epub 2013 Nov 15. PubMed PMID: 24262970.



Côrte-Real M, Madeo F. Yeast Programed Cell Death and Aging. Front Oncol. 2013 Nov 18;3:283. PubMed PMID: 24303368.

Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F. Spermidine-triggered autophagy ameliorates memory during aging. Autophagy. 2013 Nov 15;10(1). [Epub ahead of print] Review. PubMed PMID:

Stekovic S, Madeo F. Cell death pathways. Biochim Biophys Acta. 2013 Dec;1833(12):3447. doi: 10.1016/j.bbamcr.2013.09.016. PubMed PMID: 24238637.

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15. PubMed PMID: 24129513; PubMed Central
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Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 2013 Sep 1. doi: 10.1038/nn.3512. [Epub ahead of print] PubMed PMID: 23995066.


Guaragnella N, Palermo V, Burhans WC, Gourlay CW, Ludovico P, Madeo F, Giannattasio S, Mazzoni C. Yeast between life and death: a summary of the Ninth International Meeting on Yeast Apoptosis in Rome, Italy, 17-20 September 2012. Cell Death Differ. 2013 Sep;20(9):1281-3. doi: 10.1038/cdd.2013.71. Epub 2013 Jun 28. PubMed PMID: 23811851; PubMed Central PMCID: PMC3741504.


Sukkurwala AQ, Martins I, Wang Y, Schlemmer F, Ruckenstuhl C, Durchschlag M Michaud M, Senovilla L, Sistigu A, Ma Y, Vacchelli E, Sulpice E, Gidrol X, Zitvogel L, Madeo F, Galluzzi L, Kepp O, Kroemer G. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Cell Death Differ. 2013 Jun 21. doi: 10.1038/cdd.2013.73. [Epub ahead of print] PubMed PMID: 23787997.


Carmona-Gutierrez D, Alavian-Ghavanini A, HabernigL, Bauer MA, Hammer A, Rossmann C, Zimmermann AS, Ruckenstuhl C, Büttner S, Eisenberg T, Sattler W, Malle E, Madeo F. The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast. Cell Cycle. 2013 Jun 1;12(11):1704-12. doi: 10.4161/cc.24801. Epub 2013 May 1. PubMed PMID: 23656787; PubMed Central PMCID: PMC3713129.


Büttner S, Faes L, Reichelt WN, Broeskamp F, Habernig L, Benke S, Kourtis N, Ruli D, Carmona-Gutierrez D, Eisenberg T, D'hooge P, Ghillebert R, Franssens V, Harger A, Pieber TR, Freudenberger P, Kroemer G, Sigrist SJ, Winderickx J, Callewaert G, Tavernarakis N, Madeo F. The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models. Cell Death Differ. 2013 Mar;20(3):465-77. doi: 10.1038/cdd.2012.142. Epub 2012 Nov 16. PubMed PMID: 23154387; PubMed Central PMCID: PMC3569987.


Bauer MA, Carmona-Gutiérrez D, Ruckenstuhl C, Reisenbichler A, Megalou EV, Eisenberg T, Magnes C, Jungwirth H, Sinner FM, Pieber TR, Fröhlich KU, Kroemer G, Tavernarakis N, Madeo F. Spermidine promotes mating and fertilization efficiency in model organisms. Cell Cycle. 2013 Jan 15;12(2):346-52. doi: 10.4161/cc.23199. Epub 2012 Jan 15. PubMed PMID: 23255134; PubMed Central PMCID: PMC3575463.



Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sigrist SJ, Kroemer G, Madeo F. Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis. 2012 Oct 11;3:e401. doi: 10.1038/cddis.2012.139. PubMed PMID: 23059820; PubMed Central PMCID: PMC3481127.


Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, Galluzzi L, Adjemian S, Kepp O, Niso-Santano M, Shen S, Mariño G, Criollo A, Boilève A, Job B, Ladoire S, Ghiringhelli F, Sistigu A, Yamazaki T, Rello-Varona S, Locher C, Poirier-Colame V, Talbot M, Valent A, Berardinelli F, Antoccia A, Ciccosanti F, Fimia GM, Piacentini M, Fueyo A, Messina NL, Li M, Chan CJ, Sigl V, Pourcher G, Ruckenstuhl C, Carmona-Gutierrez D, Lazar V, Penninger JM, Madeo F, López-Otín C, Smyth MJ, Zitvogel L, Castedo M, Kroemer G. An immunosurveillance mechanism controls cancer cell ploidy. Science. 2012 Sep 28;337(6102):1678-84. PubMed PMID: 23019653.


Galluzzi L, Vitale I, Senovilla L, Eisenberg T, Carmona-Gutierrez D, Vacchelli E, Robert T, Ripoche H, Jägemann N, Paccard C, Servant N, Hupé P, Lazar V, Dessen P, Barillot E, Zischka H, Madeo F, Kroemer G. Independent transcriptional reprogramming and apoptosis induction by cisplatin. Cell Cycle. 2012 Sep 15;11(18):3472-80. doi: 10.4161/cc.21789. Epub 2012 Aug 23. PubMed PMID: 22918244; PubMed Central PMCID: PMC3466557.


Galluzzi L, Vitale I, Senovilla L, Olaussen KA, Pinna G, Eisenberg T, Goubar A, Martins I, Michels J, Kratassiouk G, Carmona-Gutierrez D, Scoazec M, Vacchelli E, Schlemmer F, Kepp O, Shen S, Tailler M, Niso-Santano M, Morselli E, Criollo A, Adjemian S, Jemaà M, Chaba K, Pailleret C, Michaud M, Pietrocola F, Tajeddine N, de La Motte Rouge T, Araujo N, Morozova N, Robert T, Ripoche H, Commo F, Besse B, Validire P, Fouret P, Robin A, Dorvault N, Girard P, Gouy S, Pautier P, Jägemann N, Nickel AC, Marsili S, Paccard C, Servant N, Hupé P, Behrens C, Behnam-Motlagh P, Kohno K, Cremer I, Damotte D, Alifano M, Midttun O, Ueland PM, Lazar V, Dessen P, Zischka H, Chatelut E, Castedo M, Madeo F, Barillot E, Thomale J, Wistuba II, Sautès-Fridman C, Zitvogel L, Soria JC, Harel-Bellan A, Kroemer G. Prognostic impact of vitamin B6 metabolism in lung cancer. Cell Rep. 2012 Aug 30;2(2):257-69. doi: 10.1016/j.celrep.2012.06.017. Epub 2012 Jul 26. PubMed PMID: 22854025.


Clapp C, Portt L, Khoury C, Sheibani S, Norman G, Ebner P, Eid R, Vali H, Mandato CA, Madeo F, Greenwood MT. 14-3-3 protects against stress-induced apoptosis. Cell Death Dis. 2012 Jul 12;3:e348. doi: 10.1038/cddis.2012.90. PubMed PMID: 22785534; PubMed Central PMCID: PMC3406589.


Ring J, Sommer C, Carmona-Gutierrez D, Ruckenstuhl C, Eisenberg T, Madeo F. The metabolism beyond programmed cell death in yeast. Exp Cell Res. 2012 Jul 1;318(11):1193-200. doi: 10.1016/j.yexcr.2012.03.019. Epub 2012 Mar 27. Review. PubMed PMID: 22480867; PubMed Central PMCID: PMC3396845.


Escoté X, Miranda M, Menoyo S, Rodríguez-Porrata B, Carmona-Gutiérrez D, Jungwirth H, Madeo F, Cordero RR, Mas A, Tinahones F, Clotet J, Vendrell J. Resveratrol induces antioxidant defence via transcription factor Yap1p. Yeast. 2012 Jul;29(7):251-63. doi: 10.1002/yea.2903. Epub 2012 Jun 6. PubMed PMID: 22674736.


Khan MJ, Rizwan Alam M, Waldeck-Weiermair M, Karsten F, Groschner L, Riederer M, Hallström S, Rockenfeller P, Konya V, Heinemann A, Madeo F, Graier WF, Malli R. Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells. J Biol Chem. 2012 Jun 15;287(25):21110-20. doi: 10.1074/jbc.M111.319129. Epub 2012 May 3. PubMed PMID: 22556413; PubMed Central PMCID: PMC3375534.


Carmona-Gutierrez D, Kroemer G, Madeo F. When death was young: an ancestral apoptotic network in bacteria. Mol Cell. 2012 Jun 8;46(5):552-4. doi: 10.1016/j.molcel.2012.05.032. PubMed PMID: 22681882.


Becker AC, Bunkenborg J, Eisenberg T, Harder LM, Schroeder S, Madeo F, Andersen JS, Dengjel J. Friend or food: different cues to the autophagosomal proteome. Autophagy. 2012 Jun;8(6):995-6. doi: 10.4161/auto.20286. Epub 2012 May 10. PubMed PMID: 22572990; PubMed Central PMCID: PMC3427271.


Carmona-Gutierrez D, Sommer C, Andryushkova A, Kroemer G, Madeo F. A higher spirit: avoiding yeast suicide during alcoholic fermentation. Cell Death Differ. 2012 Jun;19(6):913-4. doi: 10.1038/cdd.2012.31. PubMed PMID: 22562133; PubMed Central PMCID: PMC3354062.


Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J, Benada O, Frydlova I, Klocker A, Simon-Nobbe B, Jansko B, Breitenbach-Koller H, Eisenberg T, Gourlay CW, Madeo F, Burhans WC, Breitenbach M. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8658-63. doi: 10.1073/pnas.1201629109. Epub 2012 May 14. PubMed PMID: 22586098; PubMed Central PMCID: PMC3365156.


Klionsky DJ et al Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544. PubMed PMID: 22966490; PubMed Central PMCID: PMC3404883.


Aflaki E, Doddapattar P, Radović B, Povoden S, Kolb D, Vujić N, Wegscheider M, Koefeler H, Hornemann T, Graier WF, Malli R, Madeo F, Kratky D. C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. Cell Death Dis. 2012 Mar 15;3:e280. doi: 10.1038/cddis.2012.17. PubMed PMID: 22419109; PubMed Central PMCID: PMC3317349.


Zechner R, Zimmermann R, Eichmann TO, Kohlwein SD, Haemmerle G, Lass A, Madeo F. FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012 Mar 7;15(3):279-91. doi: 10.1016/j.cmet.2011.12.018. Review. PubMed PMID: 22405066; PubMed Central PMCID: PMC3314979.


Rodríguez-Porrata B, Carmona-Gutierrez D, Reisenbichler A, Bauer M, Lopez G, Escoté X, Mas A, Madeo F, Cordero-Otero R. Sip18 hydrophilin prevents yeast cell death during desiccation stress. J Appl Microbiol. 2012 Mar;112(3):512-25. doi: 10.1111/j.1365-2672.2011.05219.x. Epub 2012 Jan 9. PubMed PMID: 22181064.


Dengjel J, Høyer-Hansen M, Nielsen MO, Eisenberg T, Harder LM, Schandorff S, Farkas T, Kirkegaard T, Becker AC,  Schroeder S, Vanselow K, Lundberg E, Nielsen MM, Kristensen AR, Akimov V, Bunkenborg J, Madeo F, Jäättelä M, Andersen JS. Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. Mol Cell Proteomics. 2012 Mar;11(3):M111.014035. doi: 10.1074/mcp.M111.014035. Epub 2012 Feb 6. PubMed PMID: 22311637; PubMed Central PMCID: PMC3316729.


Lefevre S, Sliwa D, Auchère F, Brossas C, Ruckenstuhl C, Boggetto N, Lesuisse E, Madeo F, Camadro JM, Santos R. The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells. FEBS Lett. 2012 Jan 20;586(2):143-8. doi: 10.1016/j.febslet.2011.12.002. Epub 2011 Dec 7. PubMed PMID: 22155640.


Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nuñez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012 Jan;19(1):107-20. doi: 10.1038/cdd.2011.96. Epub 2011 Jul 15. Review. PubMed PMID: 21760595; PubMed Central PMCID: PMC3252826.


Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW, Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nyström T, Büttner S, Eisenberg T, Madeo F, Ralser M. The role of mitochondria in the aging processes of yeast. Subcell Biochem. 2012;57:55-78. doi: 10.1007/978-94-007-2561-4_3. PubMed PMID: 22094417.


Carmona-Gutierrez D, Ruckenstuhl C, Bauer MA, Netzberger C, Eisenberg T, Braun RJ, Rockenfeller P, Khoury CM, Moitzi B, Sommer C, Ring J, Schroeder S, Habernig L, Mazzoni C, Winderickx J, Gourlay CW, Madeo F. A new Canterbury tale: the eighth International Meeting on Yeast Apoptosis in Canterbury, UK, 2-6 May 2011. Cell Death Differ. 2011  Dec;18(12):1948-9. doi: 10.1038/cdd.2011.115. Epub 2011 Sep 2. PubMed PMID: 21886177; PubMed Central PMCID: PMC3214903.


Carmona-Gutierrez D, Reisenbichler A, Heimbucher P, Bauer MA, Braun RJ, Ruckenstuhl C, Büttner S, Eisenberg T, Rockenfeller P, Fröhlich KU, Kroemer G, Madeo F. Ceramide triggers metacaspase-independent mitochondrial cell death in yeast. Cell Cycle. 2011 Nov 15;10(22):3973-8. doi: 10.4161/cc.10.22.18212. Epub 2011 Nov 15. PubMed PMID: 22071627.


Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V. Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast. Biochem Soc Trans. 2011 Oct;39(5):1476-81. doi: 10.1042/BST0391476. Review. PubMed PMID: 21936837.


Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439. PubMed PMID: 21857651; PubMed Central PMCID: PMC3244833.


Morselli E, Shen S, Ruckenstuhl C, Bauer MA, Mariño G, Galluzzi L, Criollo A, Michaud M, Maiuri MC, Chano T, Madeo F, Kroemer G. p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200. Cell Cycle. 2011 Aug 15;10(16):2763-9. Epub 2011 Aug 15. PubMed PMID: 21775823.


Minois N, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging (Albany NY). 2011 Aug;3(8):716-32. Review. PubMed PMID: 21869457; PubMed Central PMCID: PMC3184975.


Büttner S, Ruli D, Vögtle FN, Galluzzi L, Moitzi B, Eisenberg T, Kepp O, Habernig L, Carmona-Gutierrez D, Rockenfeller P, Laun P, Breitenbach M, Khoury C, Fröhlich KU, Rechberger G, Meisinger C, Kroemer G, Madeo F. A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J. 2011 Jun 14;30(14):2779-92. doi: 10.1038/emboj.2011.197. PubMed PMID: 21673659; PubMed Central PMCID: PMC3160254.


Braun RJ, Sommer C, Carmona-Gutierrez D, Khoury CM, Ring J, Büttner S, Madeo F. Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast. J Biol Chem. 2011 Jun 3;286(22):19958-72. doi: 10.1074/jbc.M110.194852. Epub 2011 Apr 6. PubMed PMID: 21471218; PubMed Central PMCID: PMC3103370.


Mariño G, Morselli E, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. Longevity-relevant regulation of autophagy at the level of the acetylproteome. Autophagy. 2011 Jun;7(6):647-9. Epub 2011 Jun 1. PubMed PMID: 21460620.


Carmona-Gutiérrez D, Bauer MA, Ring J, Knauer H, Eisenberg T, Büttner S, Ruckenstuhl C,  Reisenbichler A, Magnes C, Rechberger GN, Birner-Gruenberger R, Jungwirth H, Fröhlich KU, Sinner F, Kroemer G, Madeo F. The propeptide of yeast cathepsin D inhibits programmed necrosis. Cell Death Dis. 2011 May 19;2:e161.doi: 10.1038/cddis.2011.43. PubMed PMID: 21593793; PubMed Central PMCID: PMC3122122.


Mariño G, Madeo F, Kroemer G. Autophagy for tissue homeostasis and neuroprotection. Curr Opin Cell Biol. 2011 Apr;23(2):198-206. doi: 10.1016/j.ceb.2010.10.001. Epub 2010 Oct 26. Review. PubMed PMID: 21030235.


Aerts AM, Bammens L, Govaert G, Carmona-Gutierrez D, Madeo F, Cammue BP, Thevissen K. The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans. Front Microbiol. 2011 Mar 16;2:47. doi: 10.3389/fmicb.2011.00047. PubMed PMID: 21993350; PubMed Central PMCID: PMC3128936.


Aflaki E, Radovic B, Chandak PG, Kolb D, Eisenberg T, Ring J, Fertschai I, Uellen A, Wolinski H, Kohlwein SD, Zechner R, Levak-Frank S, Sattler W, Graier WF, Malli R, Madeo F, Kratky D. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem. 2011 Mar 4;286(9):7418-28. doi: 10.1074/jbc.M110.175703. Epub 2011 Jan 1. PubMed PMID: 21196579; PubMed Central PMCID: PMC3044998.


Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol. 2011 Feb 21;192(4):615-29. doi: 10.1083/jcb.201008167. PubMed PMID: 21339330; PubMed Central PMCID: PMC3044119.


Galluzzi L, Vanden Berghe T, Vanlangenakker N, Buettner S, Eisenberg T, Vandenabeele P, Madeo F, Kroemer G. Programmed necrosis from molecules to health and disease. Int Rev Cell Mol Biol. 2011;289:1-35. doi: 10.1016/B978-0-12-386039-2.00001-8. Review. PubMed PMID: 21749897.



Laschober GT, Ruli D, Hofer E, Muck C, Carmona-Gutierrez D, Ring J, Hutter E, Ruckenstuhl C, Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C, Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Berger P, Wieser M, Grillari-Voglauer R, Thallinger GG, Grillari J, Trajanoski Z, Madeo F, Lepperdinger G, Jansen-Dürr P. Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell. 2010 Dec;9(6):1084-97. doi: 10.1111/j.1474-9726.2010.00637.x. Epub 2010 Oct 28. PubMed PMID: 20883526; PubMed Central PMCID: PMC2997327.


Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J. A stress-responsive system for mitochondrial protein degradation. Mol Cell. 2010 Nov 12;40(3):465-80. doi: 10.1016/j.molcel.2010.10.021. PubMed PMID: 21070972; PubMed Central PMCID: PMC2998070.


Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J. Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. PLoS One. 2010 Oct 27;5(10):e13700. doi: 10.1371/journal.pone.0013700. PubMed PMID: 21060871; PubMed Central PMCID: PMC2965147.


Carmona-Gutierrez D, Jungwirth H, Eisenberg T, Madeo F. Cell cycle control of cell death in yeast. Cell Cycle. 2010 Oct 15;9(20):4046. PubMed PMID: 21058425.


Ruckenstuhl C, Carmona-Gutierrez D, Madeo F. The sweet taste of death: glucose triggers apoptosis during yeast chronological aging. Aging (Albany NY). 2010 Oct;2(10):643-9. Review. PubMed PMID: 21076182; PubMed Central PMCID: PMC2993794.


Carmona-Gutierrez D, Jungwirth H, Eisenberg T, Madeo F. Cell cycle control of cell death in yeast. Cell Cycle. 2010 Oct;9(20):4046. Epub 2010 Oct 15. PubMed PMID: 20980804.


Madeo F, Tavernarakis N, Kroemer G. Can autophagy promote longevity? Nat Cell Biol. 2010 Sep;12(9):842-6. doi: 10.1038/ncb0910-842. PubMed PMID: 20811357.


Rockenfeller P, Ring J, Muschett V, Beranek A, Buettner S, Carmona-Gutierrez D, Eisenberg T, Khoury C, Rechberger G, Kohlwein SD, Kroemer G, Madeo F. Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle. 2010 Jul 15;9(14):2836-42. Epub 2010 Jul 11. PubMed PMID: 20647757.


Carmona-Gutierrez D, Ruckenstuhl C, Bauer MA, Eisenberg T, Büttner S, Madeo F. Cell death in yeast: growing applications of a dying buddy. Cell Death Differ. 2010 May;17(5):733-4. doi: 10.1038/cdd.2010.10. PubMed PMID: 20383156.


Carmona-Gutierrez D, Eisenberg T, Büttner S, Meisinger C, Kroemer G, Madeo F. Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ. 2010 May;17(5):763-73. doi: 10.1038/cdd.2009.219. Epub 2010 Jan 15. Review. PubMed PMID: 20075938.


Rockenfeller P, Madeo F. Ageing and eating. Biochim Biophys Acta. 2010 Apr;1803(4):499-506. doi: 10.1016/j.bbamcr.2010.01.001. Epub 2010 Jan 13. Review.  PubMed PMID: 20079384.


Carmona-Gutierrez D, Fröhlich KU, Kroemer G, Madeo F. Metacaspases are caspases. Doubt no more. Cell Death Differ. 2010 Mar;17(3):377-8. doi: 10.1038/cdd.2009.198. PubMed PMID: 20154701.


Braun RJ, Büttner S, Ring J, Kroemer G, Madeo F. Nervous yeast: modeling neurotoxic cell death. Trends Biochem Sci. 2010 Mar;35(3):135-44. doi: 10.1016/j.tibs.2009.10.005. Epub 2009 Nov 18. Review. PubMed PMID: 19926288.


Thevissen K, Yen WL, Carmona-Gutierrez D, Idkowiak-Baldys J, Aerts AM, François IE, Madeo F, Klionsky DJ, Hannun YA, Cammue BP. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2010Feb;303(2):163-8. doi: 10.1111/j.1574-6968.2009.01869.x. Epub 2009 Nov 27. PubMed PMID: 20030721; PubMed Central PMCID: PMC2818745.


Eisenberg T, Carmona-Gutierrez D, Büttner S, Tavernarakis N, Madeo F. Necrosis in yeast. Apoptosis. 2010 Jan 13. [Epub ahead of print] PubMed PMID: 20069456.


Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 2010 Jan;6(1):160-2. Review. PubMed PMID: 20110777.


Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G. The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy. 2010 Jan;6(1):186-8. Epub 2010 Jan 2. Review. PubMed PMID: 20023410.



Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 2010;1:e10. doi: 10.1038/cddis.2009.8. PubMed PMID: 21364612; PubMed Central PMCID: PMC3032517.


Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Tavernarakis N, Madeo F, Kroemer G. Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging (Albany NY). 2009 Dec 23;1(12):961-70.  Review. PubMed PMID: 20157579; PubMed Central PMCID: PMC2815753.


Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. PubMed PMID: 19801973.


Madeo F, Eisenberg T, Kroemer G. Autophagy for the avoidance of neurodegeneration. Genes Dev. 2009 Oct 1;23(19):2253-9. doi: 10.1101/gad.1858009. PubMed PMID: 19797764; PubMed Central PMCID: PMC2758740.


Aerts AM, Carmona-Gutierrez D, Lefevre S, Govaert G, François IE, Madeo F, Santos R, Cammue BP, Thevissen K. The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans. FEBS Lett. 2009 Aug 6;583(15):2513-6. doi: 10.1016/j.febslet.2009.07.004. Epub 2009 Jul 14. PubMed PMID: 19596007.


Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S,  Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Review. PubMed PMID: 19373242; PubMed Central PMCID: PMC2757140.


Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kössler S, Klinger H, Hager M, Bogengruber E, Jarolim S, Simon-Nobbe B, Schüller C, Carmona-Gutierrez D, Breitenbach-Koller L, Mück C, Jansen-Dürr P, Criollo A, Kroemer G, Madeo F, Breitenbach M. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY). 2009 Jul 13;1(7):622-36. PubMed PMID: 20157544; PubMed Central PMCID: PMC2806038.


Madeo F, Carmona-Gutierrez D, Ring J, Büttner S, Eisenberg T, Kroemer G. Caspase-dependent and caspase-independent cell death pathways in yeast. Biochem Biophys Res Commun. 2009 May 1;382(2):227-31. doi: 10.1016/j.bbrc.2009.02.117. Epub 2009 Feb 27. Review. PubMed PMID: 19250922.


Zechner R, Madeo F. Cell biology: Another way to get rid of fat. Nature. 2009 Apr 30;458(7242):1118-9. doi: 10.1038/4581118a. PubMed PMID: 19407787. 

Madeo F, Kroemer G. Intricate links between ER stress and apoptosis. Mol Cell. 2009 Mar 27;33(6):669-70. doi: 10.1016/j.molcel.2009.03.002. PubMed PMID:19328058.


Kepp O, Senovilla L, Galluzzi L, Panaretakis T, Tesniere A, Schlemmer F, Madeo F, Zitvogel L, Kroemer G. Viral subversion of immunogenic cell death. Cell Cycle. 2009 Mar 15;8(6):860-9. Epub 2009 Mar 26. Review. PubMed PMID: 19221507.


Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC, Durchschlag M, Joza N, Pierron G, van Endert P, Yuan J, Zitvogel L, Madeo F, Williams DB, Kroemer G. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009Mar 4;28(5):578-90. doi:10.1038/emboj.2009.1. Epub 2009 Jan 22. PubMed PMID: 19165151; PubMed Central PMCID: PMC2657583.


Madeo F, Durchschlag M, Kepp O, Panaretakis T, Zitvogel L, Fröhlich KU, Kroemer G. Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals. Cell Cycle. 2009 Feb 15;8(4):639-42. Epub 2009 Feb 8. PubMed PMID: 19182525.


Almeida B, Ohlmeier S, Almeida AJ, Madeo F, Leão C, Rodrigues F, Ludovico P. Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway. Proteomics. 2009 Feb;9(3):720-32. doi: 10.1002/pmic.200700816. PubMed PMID: 19137548.


Aerts AM, Zabrocki P, Govaert G, Mathys J, Carmona-Gutierrez D, Madeo F, Winderickx J, Cammue BP, Thevissen K. Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast. FEBS Lett. 2009 Jan 5;583(1):113-7. doi: 10.1016/j.febslet.2008.11.028. Epub 2008 Dec 4. PubMed PMID:19059240.


Ruckenstuhl C, Büttner S, Carmona-Gutierrez D, Eisenberg T, Kroemer G, Sigrist SJ, Fröhlich KU, Madeo F. The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer. PLoS One. 2009;4(2):e4592. doi:  10.1371/journal.pone.0004592. Epub 2009 Feb 25. PubMed PMID: 19240798; PubMed Central PMCID: PMC2643009.



Thevissen K, Madeo F, Ludovico P, Cammue B, Winderickx J. Joined in death: highlights of the Sixth International Meeting on Yeast Apoptosis in Leuven, Belgium, 30 April-4 May 2008. Yeast. 2008 Dec;25(12):927-34. doi: 10.1002/yea.1640. PubMed PMID: 19160457.


Bener Aksam E, Jungwirth H, Kohlwein SD, Ring J, Madeo F, Veenhuis M, van der Klei IJ. Absence of the peroxiredoxin Pmp20 causes peroxisomal protein leakage and necrotic cell death. Free Radic Biol Med. 2008 Oct 15;45(8):1115-24. doi: 10.1016/j.freeradbiomed.2008.07.010. Epub 2008 Jul 25. PubMed PMID: 18694816.


Rockenfeller P, Madeo F. Apoptotic death of ageing yeast. Exp Gerontol. 2008 Oct;43(10):876-81. doi: 10.1016/j.exger.2008.08.044. Epub 2008 Aug 26. Review. PubMed PMID: 18782613.


Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, Fimia GM, Kepp O, Piacentini M, Froehlich KU, van Endert P, Zitvogel L, Madeo F, Kroemer G. The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ. 2008 Sep;15(9):1499-509. doi: 10.1038/cdd.2008.67. Epub 2008 May 9. PubMed PMID: 18464797.


Jungwirth H, Ring J, Mayer T, Schauer A, Büttner S, Eisenberg T, Carmona-Gutierrez D, Kuchler K, Madeo F. Loss of peroxisome function triggers necrosis. FEBS Lett. 2008 Aug 20;582(19):2882-6. doi: 10.1016/j.febslet.2008.07.023. Epub 2008 Jul 24. PubMed PMID: 18656474.


Low CP, Shui G, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR, Yang H. Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast. J Cell Sci. 2008 Aug 15;121(Pt 16):2671-84. doi: 10.1242/jcs.028977. Epub 2008 Jul 24. PubMed PMID: 18653539.


Madeo F, Fröhlich KU. Apoptosis in yeast. Preface. Biochim Biophys Acta. 2008 Jul;1783(7):1271. doi: 10.1016/j.bbamcr.2008.05.009. Epub 2008 May 23. PubMed PMID: 18519044.


Galluzzi L, Joza N, Tasdemir E, Maiuri MC, Hengartner M, Abrams JM, Tavernarakis N, Penninger J, Madeo F, Kroemer G. No death without life: vital functions of apoptotic effectors. Cell Death Differ. 2008 Jul;15(7):1113-23. doi: 10.1038/cdd.2008.28. Epub 2008 Feb 29. Review. PubMed PMID: 18309324; PubMed Central PMCID: PMC2917777.


Aerts AM, Zabrocki P, François IE, Carmona-Gutierrez D, Govaert G, Mao C, Smets B, Madeo F, Winderickx J, Cammue BP, Thevissen K. Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast. Cell Mol Life Sci. 2008 Jun;65(12):1933-42. doi: 10.1007/s00018-008-8129-8. PubMed PMID: 18500447.


Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol. 2008 Jun;10(6):676-87. doi: 10.1038/ncb1730. Epub 2008 May 4. PubMed PMID: 18454141; PubMed Central PMCID: PMC2676564.


Büttner S, Bitto A, Ring J, Augsten M, Zabrocki P, Eisenberg T, Jungwirth H, Hutter S, Carmona-Gutierrez D, Kroemer G, Winderickx J, Madeo F. Functional mitochondria are required for alpha-synuclein toxicity in aging yeast. J Biol Chem. 2008 Mar 21;283(12):7554-60. doi: 10.1074/jbc.M708477200. Epub 2008 Jan 11. PubMed PMID: 18192273.



Almeida B, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osório NS, Kollau A, Mayer B, Leão C, Laranjinha J, Rodrigues F, Madeo F, Ludovico P. NO-mediated apoptosis in yeast. J Cell Sci. 2007 Sep 15;120(Pt 18):3279-88. Epub 2007 Aug 28. PubMed PMID: 17726063.


Büttner S, Carmona-Gutierrez D, Vitale I, Castedo M, Ruli D, Eisenberg T, Kroemer G, Madeo F. Depletion of endonuclease G selectively kills polyploid cells. Cell Cycle. 2007 May 2;6(9):1072-6. Epub 2007 May 27. PubMed PMID: 17471024.


Eisenberg T, Büttner S, Kroemer G, Madeo F. The mitochondrial pathway in yeast apoptosis. Apoptosis. 2007 May;12(5):1011-23. Review. PubMed PMID: 17453165.


Büttner S, Carmona-Gutierrez D, Eisenberg T, Ruli D, Madeo F. Conspiracy of yeast killers: the fifth international meeting on yeast apoptosis in Prague, Czech Republic, 3-7 September, 2006. FEMS Yeast Res. 2007 Mar;7(2):351-4. PubMed PMID: 17313593.


Büttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, Ruckenstuhl C, Sigrist C, Wissing S, Kollroser M, Fröhlich KU, Sigrist S, Madeo F. Endonuclease G regulates budding yeast life and death. Mol Cell. 2007 Jan 26;25(2):233-46. PubMed PMID: 17244531.



Büttner S, Eisenberg T, Herker E, Carmona-Gutierrez D, Kroemer G, Madeo F. Why yeast cells can undergo apoptosis: death in times of peace, love, and war. J Cell Biol. 2006 Nov 20;175(4):521-5. Epub 2006 Nov 13. Review. PubMed PMID: 17101700; PubMed Central PMCID: PMC2064587.


Carmona-Gutierrez D, Madeo F. Yeast unravels epigenetic apoptosis control: deadly chat within a histone tail. Mol Cell. 2006 Oct 20;24(2):167-9. Review. PubMed PMID: 17052450.


Braun RJ, Zischka H, Madeo F, Eisenberg T, Wissing S, Büttner S, Engelhardt SM, Büringer D, Ueffing M. Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. J Biol Chem. 2006 Sep 1;281(35):25757-67. Epub 2006 Jul 5. PubMed PMID: 16822868.


Ramachandran L, Burhans DT, Laun P, Wang J, Liang P, Weinberger M, Wissing S, Jarolim S, Suter B, Madeo F, Breitenbach M, Burhans WC. Evidence for ORC-dependent repression of budding yeast genes induced by starvation and other stresses. FEMS Yeast Res. 2006 Aug;6(5):763-76. PubMed PMID: 16879427.


Allen C, Büttner S, Aragon AD, Thomas JA, Meirelles O, Jaetao JE, Benn D, Ruby SW, Veenhuis M, Madeo F, Werner-Washburne M. Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures. J Cell Biol. 2006 Jul 3;174(1):89-100. PubMed PMID: 16818721; PubMed Central PMCID: PMC2064167.


Rinnerthaler M, Jarolim S, Heeren G, Palle E, Perju S, Klinger H, Bogengruber E, Madeo F, Braun RJ, Breitenbach-Koller L, Breitenbach M, Laun P. MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochim Biophys Acta. 2006 May-Jun;1757(5-6):631-8. Epub 2006 May 20. PubMed PMID: 16806052.


Modjtahedi N, Giordanetto F, Madeo F, Kroemer G. Apoptosis-inducing factor: vital and lethal. Trends Cell Biol. 2006 May;16(5):264-72. Epub 2006 Apr 18. Review. PubMed PMID: 16621561.


Vahsen N, Candé C, Dupaigne P, Giordanetto F, Kroemer RT, Herker E, Scholz S, Modjtahedi N, Madeo F, Le Cam E, Kroemer G. Physical interaction of apoptosis-inducing factor with DNA and RNA. Oncogene. 2006 Mar  16;25(12):1763-74. PubMed PMID: 16278674.


Hauptmann P, Riel C, Kunz-Schughart LA, Fröhlich KU, Madeo F, Lehle L. Defects in N-glycosylation induce apoptosis in yeast. Mol Microbiol. 2006 Feb;59(3):765-78. PubMed PMID: 16420350.



Laun P, Ramachandran L, Jarolim S, Herker E, Liang P, Wang J, Weinberger M, Burhans DT, Suter B, Madeo F, Burhans WC, Breitenbach M. A comparison of the aging and apoptotic transcriptome of Saccharomyces cerevisiae. FEMS Yeast Res. 2005 Dec;5(12):1261-72. Epub 2005 Aug 31. PubMed PMID: 16168721.


Mazzoni C, Herker E, Palermo V, Jungwirth H, Eisenberg T, Madeo F, Falcone C. Yeast caspase 1 links messenger RNA stability to apoptosis in yeast. EMBO Rep. 2005 Nov;6(11):1076-81. Epub 2005 Sep 9. PubMed PMID: 16170310; PubMed Central PMCID: PMC1371024.


Ludovico P, Madeo F, Silva M. Yeast programmed cell death: an intricate puzzle. IUBMB Life. 2005 Mar;57(3):129-35. Review. PubMed PMID: 16036575.


Reiter J, Herker E, Madeo F, Schmitt MJ. Viral killer toxins induce caspase-mediated apoptosis in yeast. J Cell Biol. 2005 Jan 31;168(3):353-8. Epub 2005 Jan 24. PubMed PMID: 15668299; PubMed Central PMCID: PMC2171720.



Madeo F, Herker E, Wissing S, Jungwirth H, Eisenberg T, Fröhlich KU. Apoptosis in yeast. Curr Opin Microbiol. 2004 Dec;7(6):655-60. Review. PubMed PMID: 15556039.


Wissing S, Ludovico P, Herker E, Büttner S, Engelhardt SM, Decker T, Link A, Proksch A, Rodrigues F, Corte-Real M, Fröhlich KU, Manns J, Candé C, Sigrist SJ, Kroemer G, Madeo F. An AIF orthologue regulates apoptosis in yeast. J Cell Biol. 2004 Sep 27;166(7):969-74. Epub 2004 Sep 20. PubMed PMID: 15381687; PubMed Central PMCID: PMC2172025.


Wadskog I, Maldener C, Proksch A, Madeo F, Adler L. Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Mol Biol Cell. 2004 Mar;15(3):1436-44. Epub 2004 Jan 12. PubMed PMID: 14718573; PubMed Central PMCID: PMC363166.


Herker E, Jungwirth H, Lehmann KA, Maldener C, Fröhlich KU, Wissing S, Büttner S, Fehr M, Sigrist S, Madeo F. Chronological aging leads to apoptosis in yeast. J Cell Biol. 2004 Feb 16;164(4):501-7. PubMed PMID: 14970189; PubMed Central PMCID: PMC2171996.


Swan LE, Wichmann C, Prange U, Schmid A, Schmidt M, Schwarz T, Ponimaskin E, Madeo F, Vorbrüggen G, Sigrist SJ. A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. Genes Dev. 2004 Jan 15;18(2):223-37. Epub 2004 Jan 16. PubMed PMID: 14729572; PubMed Central PMCID: PMC324427.



Mazzoni C, Mancini P, Madeo F, Palermo V, Falcone C. A Kluyveromyces lactis mutant in the essential gene KlLSM4 shows phenotypic markers of apoptosis. FEMS Yeast Res. 2003 Oct;4(1):29-35. PubMed PMID: 14554194.


Mazzoni C, Mancini P, Verdone L, Madeo F, Serafini A, Herker E, Falcone C. A truncated form of KlLsm4p and the absence of factors involved in mRNA decapping trigger apoptosis in yeast. Mol Biol Cell. 2003 Feb;14(2):721-9. Erratum in: Mol Biol Cell. 2003 Apr;14(4):following 1743. PubMed PMID: 12589065; PubMed Central PMCID: PMC150003.



Madeo F, Fröhlich KU. Comment on Severin, F.F., and Hyman, A.A. (2002). Pheromone induces programmed cell death in S. cerevisiae. Curr. Biol. 12, R233-R235. Curr Biol. 2002 Jul 9;12(13):R445. Review. PubMed PMID: 12121632. 



Fröhlich KU, Madeo F. Apoptosis in yeast: a new model for aging research. Exp Gerontol. 2001 Dec;37(1):27-31. Review. PubMed PMID: 11738144.


Ligr M, Velten I, Fröhlich E, Madeo F, Ledig M, Fröhlich KU, Wolf DH, Hilt W. The proteasomal substrate Stm1 participates in apoptosis-like cell death in yeast. Mol Biol Cell. 2001 Aug;12(8):2422-32. PubMed PMID: 11514626; PubMed Central PMCID: PMC58604.


Laun P, Pichova A, Madeo F, Fuchs J, Ellinger A, Kohlwein S, Dawes I, Fröhlich KU, Breitenbach M. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol. 2001 Mar;39(5):1166-73. PubMed PMID: 11251834.



Fröhlich KU, Madeo F. Apoptosis in yeast--a monocellular organism exhibits altruistic behaviour. FEBS Lett. 2000 May 4;473(1):6-9. Review. PubMed PMID: 10802048.



Madeo F, Fröhlich E, Ligr M, Grey M, Sigrist SJ, Wolf DH, Fröhlich KU. Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol. 1999 May 17;145(4):757-67. PubMed PMID: 10330404; PubMed Central PMCID: PMC2133192.



Ligr M, Madeo F, Fröhlich E, Hilt W, Fröhlich KU, Wolf DH. Mammalian Bax triggers apoptotic changes in yeast. FEBS Lett. 1998 Oct 30;438(1-2):61-5. PubMed PMID: 9821959.



Madeo F, Schlauer J, Fröhlich KU. Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiae. Gene. 1997 Dec 19;204(1-2):145-51. PubMed PMID: 9434177.


Madeo F, Fröhlich E, Fröhlich KU. A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol. 1997 Nov 3;139(3):729-34. PubMed PMID: 9348289; PubMed Central PMCID: PMC2141703.


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